Synthetic Biology: Genetic Firewalls to Horizontal Gene Transfer - Group 2

Опубликовано: 05 Январь 2016
на канале: iBiology Techniques

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https://www.ibiology.org/bioengineeri...

Synthetic biology can be used to create biofuels, therapeutics, biosensors, and bioremediation. This often involves introducing new DNA into an existing organism. However, at the same time, it is important to also develop genetic safeguards to ensure that this new DNA is not unwillingly transferred to another organism. One safeguard is to create an organism lacking key DNA repair enzymes (UNG and DUT) that are responsible for fixing misincorporated uracil in the genome. Therefore, this organism will accumulate uracil mutations in its genome, and if it mates with another organism the uracil mutated genome will be recognized as faulty and destroyed. The Synthetic Biology in action participants describe these different safeguarding mechanisms and how they created a host organism with UNG and DUT deletions.

Speakers:
Yu Heng Lau, Post-doctoral scholar at Harvard Medical School
Roberto Ferro, PhD student at the Technical University of Denmark
Dario Neves, PhD student at RWTH Aachen University
Jason Whitfield, PhD student at the Australian National University, Canberra