From Motifs to Pathways and Master-regulators (RNA-Seq + ChIP-Seq) using Genome Enhancer - PART 2
Welcome back to the continuation of this series! In this video, I pick up where I left off in part 1, exploring the detailed report generated by Genome Enhancer. Join me as I delve into the comprehensive analysis of multi-omics data, identifying master-regulators using geneXplain's automated pipeline. Genome Enhancer's user-friendly point-and-click interface remains the go-to tool for uncovering transcription factor binding sites (TFBS), master regulators, potential drug targets, and their corresponding treatments. Throughout this session, I'll guide you through the fully automated pipeline, unraveling the molecular mechanism of the studied pathology and providing insights like never before.
This video is in collaboration with geneXplain GmbH ( / @genexplain ) which is one of the worldwide known providers of top bioinformatics, systems biology and cheminformatics databases, software and services.
I hope you find this video helpful! Leave your thoughts in the comment section below!
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▸ PART 1:
• From Motifs to Pathways and Master-re...
▸ Other videos in this series:
1. • Introduction to Motif Discovery and T...
2. • Motif discovery and enrichment in gen...
▸ Data used for demonstration:
Epigenomics: https://www.ncbi.nlm.nih.gov/geo/quer...
Transcriptomics: https://www.ncbi.nlm.nih.gov/geo/quer...
▸ geneXplain's Genome Enhancer playlist:
• Genome Enhancer
▸ Description of databases:
https://genexplain-platform-documenta...
▸ Contact geneXplain:
https://genexplain.com/contact/
Chapters:
0:00 Intro
0:24 Overview of detailed report
1:15 Abstract
2:22 Introduction and Data section
3:13 Results: Identification of target genes
5:13 Results: Functional classification of genes
8:27 Results: Analysis of enriched TFBS and composite modules
13:41 Results: Finding master regulators
16:19 Results: Finding prospective drug targets
18:03 Results: Identification of Potential drugs
19:37 Conclusion
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To get in touch:
Website: https://bioinformagician.org/
Github: https://github.com/kpatel427
Email: [email protected]
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